N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
CAS No. 4272-74-6
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride ( N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride;N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride )
Catalog No. M26766 CAS No. 4272-74-6
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride is an inhibitor of trypsin-like protease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 43 | In Stock |
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10MG | 67 | In Stock |
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25MG | 113 | In Stock |
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50MG | 167 | In Stock |
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100MG | Get Quote | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameN-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionN-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride is an inhibitor of trypsin-like protease.
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DescriptionN-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride is an inhibitor of trypsin-like protease. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride exhibits an inhibitory effect on IFN-γ activities.(In Vitro):A lower concentration of anti-Fas (10 ng/mL) is used to examine the interaction among the three effectors simultaneously, that is, anti-Fas, TLCK, and IFN-γ. N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (50 μM) exhibits a small decrease in cell viability. Beyond 50 μM, a dose-dependent decrease in cell viability is observed. IFN-γ slightly reduces cell viability on its own. The addition of anti-Fas (10 ng/mL) results in a slight decrease in cell survival, which is enhanced more than additively in the presence of TLCK, most prominently between 50 and 100 μM. Upon addition of both anti-Fas and IFN-γ, a decrease (≈46%) in cell viability is observed. Moreover, the decrease in cell survival is further enhanced by the addition of higher concentrations of TLCK, 25 μM, and more.
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SynonymsN-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride;N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number4272-74-6
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Formula Weight369.3
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Molecular FormulaC14H22Cl2N2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=S(C1=CC=C(C)C=C1)(N[C@H](C(CCl)=O)CCCCN)=O.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lim B, et al. A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three-Dimensional Fluorescence Emission Computed Tomography (FLECT) Technology. Theranostics. 2017 Feb 26;7(5):1047-1061.
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